Cong Wen of Xixiakou Wildlife Zoo in eastern China says four cubs called ligers were born to a lion and tiger in May.
She said the tiger mother fed the ligers for four days but then abandoned them for unknown reasons. Two died of weakness.
Cong said staff at the zoo in Shandong province found a female dog who had just given birth to feed the surviving cubs.
She said the two cubs had trouble at first drinking milk from the dog but are now used to it.
Ligers are rare and are sometimes bred in zoos by mistake.